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Last Updated: February 2026

Best GLP-1 Treatments for Weight Loss in 2026

Science-backed medications. Trusted telehealth providers. Real results.

Access GLP-1 treatments like semaglutide and tirzepatide, including Wegovy®, Ozempic®, and Mounjaro®, for effective weight management — all from the comfort of your home.

Medically Reviewed by

Licensed Healthcare Professionals

Our Top Picks

10 providers compared
Our Top Pick
1Ro logo

Ro

  • Access FDA-approved Wegovy® GLP-1 pills, if prescribed
  • Free insurance check to understand your coverage options
  • Lose up to 20% of your body weight in a year
  • 100% online process with 24/7 provider chat
Discreet Shipping
Get $100 off your first month. No code required — applied at checkout.
9.8
Outstanding
Best for Women
2Hers logo

Hers

  • Get Ozempic®, compounded GLP-1s with semaglutide & oral kits
  • Licensed providers with 24/7 access to a care team
  • Compounded GLP-1 plans starting at $199/mo for a 6-month plan
  • Personalized treatment based on your health profile
Save $75 on your first order — limited time offer.
9.3
Excellent
3Hims logo

Hims

  • Ozempic® and compounded GLP-1s starting at $199/mo
  • 24/7 access to a care team, FSA/HSA eligible
  • Program designed by weight loss experts & nutritionists
  • No insurance required to start treatment
9.1
Excellent
4MEDVi logo

MEDVi

  • Oral and injectable GLP-1 medications including Ozempic®
  • 24/7 support and weight loss money-back guarantee
  • Save $120 + fast, free shipping on all orders
  • Budget-friendly pricing with doctor approval
Save $120 + fast, free shipping on your first order.
9.0
Excellent
5Mochi Health logo

Mochi Health

  • Dedicated physician for your treatment journey
  • Affordable GLP-1 drugs with or without insurance
  • GLP-1 medications starting from $99/mo + membership
  • Ongoing medical support throughout your plan
Get 50% off your first month of membership.
8.9
Very Good
6Eden logo

Eden

  • Compounded GLP-1s (Semaglutide and Tirzepatide) available
  • Plans from $129 for the first month
  • No insurance required, 24/7 support
  • Fast, free shipping on every order
Save $120 on your first order with code: GLP120
8.8
Very Good
7Fridays Health logo

Fridays Health

  • Oral & injectable GLP-1s with micro-dosing options
  • Dietitians, workouts, coaching, and support groups
  • Meal prep delivery available with your plan
  • Mental health coaching included at no extra cost
8.6
Very Good
8FuturHealth logo

FuturHealth

  • Access Wegovy® (pill & injection) starting at just $49
  • Tracking and delivery of weight loss medication
  • Recipes & GLP-1 friendly meals included
  • Apple Fitness+ access included with your plan
8.5
Very Good
9Henry logo

Henry

  • Compounded injectable and oral GLP-1s available
  • Start with a free, no-obligation evaluation
  • No insurance needed to get started
  • Personalized dosing and treatment plans
Get $150 off — no insurance needed.
8.5
Very Good
10SkinnyRX logo

SkinnyRX

  • Ozempic®, Wegovy®, Zepbound®, and other GLP-1s
  • 100% online doctor visits and prescriptions
  • Buy Now, Pay Later with Affirm available
  • Comprehensive medication selection to fit your needs
8.4
Very Good

Advertising Disclosure: We earn commissions from brands featured on this site. This may affect listing placement but does not influence our editorial ratings, which are based on independent research. All GLP-1 medications require a prescription from a licensed provider.

How We Compare & Rank Providers

Transparency matters. Here's how our editorial process works.

Independent Research

Our team evaluates each provider based on available medications, pricing, clinical support quality, user experience, and clinical evidence.

Scoring & Ranking

We assign scores on a 10-point scale based on medication access, cost transparency, provider credentials, customer support, and user reviews.

Regular Updates

Listings are reviewed and updated monthly to reflect new pricing, medication availability, promotions, and provider changes.

How We Earn

We receive compensation from featured providers through affiliate partnerships. This helps keep our site free for users but may influence listing placement and order.

Affiliate Disclosure: GLP-1 Guide is an independently operated comparison website. We may receive referral compensation from the providers featured on this site when you click a link or complete an action (such as filling out a form). This compensation may influence which providers appear on this page, the order in which they appear, and the ratings and scores we assign. However, our editorial opinions are our own and are not influenced by compensation. We do not include every provider on the market. All content is for informational purposes only and should not be considered medical advice.

Understanding GLP-1

What Is GLP-1 and How Does It Help You Lose Weight?

GLP-1 receptor agonists are a breakthrough class of medications reshaping how we approach weight management and metabolic health.

What Is GLP-1?

GLP-1 (Glucagon-Like Peptide-1) is a naturally occurring hormone your body produces after eating. It plays a key role in regulating appetite, blood sugar, and digestion.

GLP-1 receptor agonist medications mimic this hormone at higher levels, producing stronger and more sustained effects on appetite control and metabolic function.

How Do GLP-1 Drugs Work?

  • Signals fullness to the brain

    Reduces hunger cues so you feel satisfied with less food.

  • Slows gastric emptying

    Food stays in your stomach longer, keeping you fuller between meals.

  • Improves insulin response

    Helps your body better manage blood sugar after eating.

  • Reduces glucose production

    Lowers the amount of sugar your liver releases into the bloodstream.

Significant Weight Loss

15–22% body weight reduction in clinical studies over ~68 weeks.

Heart Health

Studies show reduced risk of cardiovascular events in some patients.

Blood Sugar Control

Improved A1C levels and better insulin sensitivity.

Appetite Regulation

Reduced cravings and feeling satisfied with smaller portions.

Medication Reference

FDA-Approved GLP-1 Medications

A comprehensive overview of GLP-1 receptor agonists available for weight loss and type 2 diabetes management.

Wegovy®

Weight Loss
Active IngredientSemaglutide (injectable)
TypeWeekly Injection
DosingOnce weekly
FDA StatusApproved for obesity

Wegovy®

Weight Loss
Active IngredientSemaglutide (oral)
TypeDaily Tablet
DosingOnce daily
FDA StatusApproved for obesity

Ozempic®

Type 2 Diabetes
Active IngredientSemaglutide (injectable)
TypeWeekly Injection
DosingOnce weekly
FDA StatusApproved for type 2 diabetes

Rybelsus®

Type 2 Diabetes
Active IngredientSemaglutide (oral)
TypeDaily Tablet
DosingOnce daily
FDA StatusApproved for type 2 diabetes

Saxenda®

Weight Loss
Active IngredientLiraglutide
TypeDaily Injection
DosingOnce daily
FDA StatusApproved for obesity

Victoza®

Type 2 Diabetes
Active IngredientLiraglutide
TypeDaily Injection
DosingOnce daily
FDA StatusApproved for type 2 diabetes

Mounjaro®

Type 2 Diabetes
Active IngredientTirzepatide (GLP-1 + GIP)
TypeWeekly Injection
DosingOnce weekly
FDA StatusApproved for type 2 diabetes*

Zepbound®

Weight Loss
Active IngredientTirzepatide (GLP-1 + GIP)
TypeWeekly Injection
DosingOnce weekly
FDA StatusApproved for obesity

* Mounjaro® is FDA-approved for type 2 diabetes. Weight loss use is considered off-label. Always consult your healthcare provider for guidance on the appropriate medication for your needs.

Compounded vs. FDA-Approved GLP-1s

Compounded GLP-1 treatments contain the same active ingredients as branded medications, but are custom-prepared by licensed compounding pharmacies and are not FDA-approved as finished products.

FDA-approved: Rigorously tested for safety and efficacy. Manufactured under strict quality controls.

Compounded: May be prescribed during shortages or for custom dosing. Quality can vary by pharmacy.

What Results Can You Expect?

First 2–4 Weeks

Appetite changes and reduced cravings begin as your body adjusts to the medication.

Months 1–3

Noticeable weight loss as dosage is gradually increased to therapeutic levels.

6–12 Months

Studies show 15–22% body weight reduction when combined with lifestyle changes.

Long-Term

Ongoing treatment is typically needed to maintain results. Your provider will guide you.

FAQ

Frequently Asked Questions

Answers to common questions about GLP-1 weight loss treatments.

Ready to Start Your Weight Loss Journey?

Compare trusted GLP-1 providers, understand your options, and take the first step toward clinically proven weight management.